UNVEILING PARRY-ROMBERG SYNDROME WITH NATIVE DEMYELINATING ETIOLOGY AS THE UNDERLYING CAUSE


Untargeted Metabolomics Analysis Reveals Toxicity Based on the Sex and Sexual Maturity of Single Low-Dose DEHP Exposure

Di-(2-Ethylhexyl) phthalate (DEHP) is a prevalent environmental endocrine disruptor that affects homeostasis, reproduction, and developmental processes.The effects of DEHP have been shown to differ based on sex and sexual maturity.This study examines the metabolic 9x11 pergola profiles of mature adult rats from both sexes, aged 10 weeks, and adoles

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Structural and biochemical characterization of SrcA, a multi-cargo type III secretion chaperone in Salmonella required for pathogenic association with a host.

Many Gram-negative bacteria colonize and exploit host niches using a protein apparatus called a type III secretion system (T3SS) that translocates bacterial effector proteins into host cells where their functions are essential for pathogenesis.A suite of T3SS-associated chaperone proteins bind cargo in the bacterial cytosol, establishing protein in

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A single cell atlas of frozen shoulder capsule identifies features associated with inflammatory fibrosis resolution

Abstract Frozen shoulder is a spontaneously self-resolving chronic inflammatory fibrotic human disease, which distinguishes the condition from most fibrotic diseases that are progressive and irreversible.Using single-cell analysis, we identify pro-inflammatory MERTKlowCD48+ macrophages and MERTK + LYVE1 + MRC1+ macrophages enriched for negative reg

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